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Connectivity Map helps characterize genetic variants in lung adenocarcinoma.

Researchers at the Dana Farber Cancer Institute, Harvard Medical School, and the Broad Institute of Harvard and MIT recently published a study in Cancer Cell describing a unique application of the Connectivity Map data set. This team used a new approach, called expression-based variant-impact phenotyping (eVIP), and CMap data to characterize the functional impact of 194 genetic variants in lung adenocarcinoma.

Access to publication: High-throughput Phenotyping of Lung Cancer Somatic Mutations.

CMap uncovers drug repurposing opportunities for osteoporosis.

Using Connectivity Map, researchers identified the compound parbendazole as an inducer of osteogenic differentiation in human mesenchymal stem cells.

Access to publication: Connectivity Map-based discovery of parbendazole reveals targetable human osteogenic pathway

Withaferin A identified as compound that reverses obesity-associated leptin resistance.

In a search for compounds that reverse the leptin resistance associated with obesity, Withaferin A showed that treatment of obese mice increased leptin potency and weight loss.

Access to publication: Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice.